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PKD is a physiologically relevant enzyme for SPHK2 phosphorylation, which leads to its nuclear export for subsequent cellular signaling Regulation of secretory transport by PKD-mediated phosphorylation of CERT is reported PKCmu activation is associated with a unique signaling pathway coupling TCR ligation with T cell proliferation
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The T-cell antigen receptor (TCR) comprises α/β subunits that recognize peptide–MHC and the signal transducing subunits γ, δ, ε and ζ (CD3 complex) This review will cover recent progress from biochemistry, genetics and cell biology towards understanding the signal transduction pathways that control T-cell activation
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Sep 27, 2016· Thymic selection shapes an appropriate T cell antigen receptor (TCR) repertoire during T cell development Here, we show that a serine/threonine kinase, protein kinase D (PKD), is crucial for .
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